Reconstitute 10 g vial with 45 ml or 96 ml of sterile water for injection, bacteriostatic water for injection, or 0. Cefazolin prices, coupons and patient assistance programs. Pr cefazolin for injection, usp cefazolin sodium powder. After reconstitution with either45mlor96mlofdiluenttheconcentrationis1gramcefazolinper5mlor1gram cefazolin per 10 ml, respectively. Dec 12, 2018 ndc 0143992390 cefazolin for injection, usp 500 mgvial for iv or im use rx only each vial contains sterile cefazolin sodium equivalent to 500 mg cefazolin. The medicine is sometimes also used to prevent infections before, during, or after. Cefazolinaft powder for injection equivalent to cefazolin 500 milligram, 1 gram and 2gram. Check with your physician if you have any of the following.
Find patient medical information for cefazolin injection on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Cefazolin does not reach therapeutic levels within the csf. Dosage adjustment for patients with reduced renal function. White to offwhite powder which reconstitutes with sterile water for injection to give a colourless. Identification of the causative organisms should be made by culture should signs of infection occur so that appropriate therapy may be instituted. Positive direct and indirect coombs tests have been reported during treatment with cefazolin. The color of cefazolin for injection, usp solutions may range from pale yellow to yellow without a change in potency. In synovial fluid, the cefazolin concentration becomes comparable to that reached in serum at about 4 hours after drug administration. Each vial contains 48 mg 2 meq of sodium1 gram of cefazolin sodium. This is not a complete list of side effects and others may occur. See microbiology for disc susceptibility tests and dilution techniques. This may increase your risk for sideeffects or cause your drug not to work properly. Package insert cefazolin for injection usp and dextrose injection usp to reduce the development of drugresistant bacteria and maintain the effectiveness of cefazolin for injection usp and dextrose injection usp and other antibacterial drugs, cefazolin for injection usp and dextrose injection usp should be used only to treat or.
Call your doctor for medical advice about side effects. Cefazolin for injection should be reconstituted with sterile water for injection, usp to a concentration of 100 mg per ml and further diluted in 50 ml of a compatible solution. In some cases, cefazolin may be more practical and. Cefazolin injection label food and drug administration. It will not work for colds, flu, or other viral infections. It offers the advantages of a moderately long halflife, activity against most staphylococci and streptococci in addition to some gramnegative aerobic organisms, and low cost. Cefazolin for injection, usp is white to offwhite crystalline powder. Pdf stability of cefazolin sodium in polypropylene. Cefazolin sodium cefazolin sodium dose, indications. Cefazolin is an antibiotic used to treat bacterial infections, marketed under the brand names ancef and kefzol. Cefazolin normon 1g powder for solution for injectioninfusion. The investigators from the druginduced liver injury network dilin report a previously unrecognized phenomenon.
Ndc 0143992390 cefazolin for injection, usp 500 mgvial for iv or im use rx only each vial contains sterile cefazolin sodium equivalent to 500 mg cefazolin. Cefazolin for injection usp may reduce the incidence of certain postoperative infections. Cefazolin exerts its bactericidal effect by inhibiting bacterial cell wall synthesis. Cefazolin cefazolin sodium injection, powder, for solution sandoz inchighlights of prescribing information these highlights do not include all the information needed to use cefazolin for injection usp safely and effectively. See full prescribing information for cefazolin for injection usp. Package insert cefazolinforinjectionusp anddextroseinjectionusp rxonly to reduce the development of drugresistant bacteria and maintain the effectiveness of cefazolin for injection usp and dextrose injection usp and other antibacterial drugs, cefazolin for injection usp and dextrose. This prescription drug is used for treating these types of bacterial infections and also for preventing certain infections that may occur due to surgery. Surgical prophylaxis 12g 3060mins before surgery, then 0. There is clinical evidence of partial crossallergenicity of.
After reconstitution with either 45 ml or 96 ml of diluent the concentration is 1 gram cefazolin per 5 ml or 1 gram cefazolin per 10 ml, respectively. Before using cefazolin injection, inform your doctor about your current list of medications, over the counter products e. It works by stopping the growth of bacteria cefazolin is available under the following different brand names. Anaphylaxis, fever, abdominal cramps, diarrhea, seizures nursing considerations. Cefazolin for injection is contraindicated in patients with known allergy to the cephalosporin group of antibiotics.
Sterile vancomycin hydrochloride, usp is a lyophilized powder, for preparing intravenous iv infusions. Cefazolin is a member of the first generation cephalosporins drug class and is commonly used for bacterial endocarditis prevention, bacterial infection, bone infection, and others. Cefazolin for injection, usp is supplied in 10 grams of cefazolin. Cefazolin for injection, usp is supplied in vials containing cefazolin sodium equivalent to 500 mg or 1 gram cefazolin. Cefazolin is the most commonly used antibiotic for prophylaxis. Cefazolin for injection usp and dextrose injection usp. Cefazolin sodium is a cephalosporin antibiotic for parenteral administration. Also available as pharmacy bulk package, as follows. Package insert cefazolinforinjectionusp anddextroseinjectionusp rxonly to reduce the development of drugresistant bacteria and maintain the effectiveness of cefazolin for injection usp and dextrose injection usp and other antibacterial drugs, cefazolin for injection usp and dextrose injection usp should. Penicillin vk penicillin is good at treating strep throat and is cheap, however, it can only be used for certain infections as many bacteria have developed resistance to it. Cefazolin distributes into breast milk in low concentrations.
Pdf stability of cefazolin sodium in polypropylene syringes. Iv administration of cefazolin to normal adult volunteers, mean peak serum concentrations were. The drug concentrates in the urine, at levels much higher than peak serum levels. Drug interactions with cefazolin antibiotics home page. Cefazolin injection fda prescribing information, side. Calcium gluconate in sodium chloride injection wg critical care. Cefazolin is also recommended as alternate therapy for penicillinsusceptible and certain resistant staphylococcal infections. Cefazolin sodium definition of cefazolin sodium by medical. Remarkably, every single patient in this case series also presented with pruritus, suggesting an allergic reaction.
Lower daily dosage of cefazolin for injection is required in patients with impaired renal function creatinine clearance less than 55 mlmin. Venofer iron sucrose injection, usp is an established and effective treatment for chronic kidney disease ckd patients experiencing iron deficiency anemia. A broadspectrum cephalosporin antibiotic, c14h14n8o4s3, that is given intravenously in the form of its sodium salt. Dec 01, 2019 cefazolin for injection, usp is supplied in vials containing cefazolin sodium equivalent to 500 mg or 1 gram cefazolin. Contraindications sterile cefazolin sodium is contraindicated in patients with known allergy to the cephalosporin.
To our knowledge, this study is the first to evaluate the clinical outcome data between two gram and three gram cefazolin dosing for surgical prophylaxis in the setting of obesity. Studies have shown that following intravenous administration of cefazolin to normal. Pneumonia, bladder infections, or various other bacterial infections may be treated with an antibiotic called cefazolin. Cefazolin for injection, usp is supplied in 10 or 20 grams pharmacy bulk packages. Use an alternative cefazolin product when lengthy surgical. Cefazolin dosing for surgical prophylaxis in morbidly. Cefazolin injection, usp in galaxy container baxter pi. Monographs for commonly administered intravenous medications in home and community care 2 p a g e cefazolin stability compatibilities3 compatible with. In an increasingly competitive market environment, apotex continually strives to introduce quality, affordable medicines to consumers. Cefazolin is an antibiotic medicine and belongs to a group of medicines called cephalosporins.
Cefazolin injection can also be given intramuscularly into a muscle. The following conditions are contraindicated with this drug. Cefazolin for injection, usp is supplied in 10 grams pharmacy bulk packages. Studies of cord blood show prompt transfer of cefazolin for injection across the placenta. Warnings cefazolin for injection should be used with caution in penicillinallergic patients. Each pharmacy bulk package contains cefazolin sodium equivalent to 10 grams of cefazolin. To reduce the development of drugresistant bacteria and maintain the. Cefazolin for injection, usp is a white to cream sterile powder. Cefazolin sodium definition of cefazolin sodium by.
Cefazolin generic ancef is a intravenous or intramuscular injection drug only. Cyclothiazide the excretion of cefazolin can be decreased when combined with inofrmation. In synovial fluid, the level of cefazolin for injection becomes comparable to that reached in serum at about 4 hours after drug administration. Highlights of prescribing information these highlights do not include all the information needed to use zerbaxasafely and effectively. Cefazolin ranks sixth as a cause of druginduced liver injury. Side effects of cefazolin injection cefazolin and dextrose. Use this formulation of cefazolin only in patients who require the. Zerbaxa ceftolozane and tazobactam for injection, for intravenous use initial u. Treatment with this medicinal product must be stopped if an allergic reaction occurs and the. Each pharmacy bulk package contains vancomycin hydrochloride equivalent to 5 grams of vancomycin base. For a 65 lb kid the dose range is 25100 mgkgday divided into 34 doses a day. Studies of cord blood show prompt transfer of cefazolin across the placenta.
It exerts its bacterial effect by inhibiting bacterial cell wall synthesis. Our cefazolin and dextrose for injection side effects drug center provides a comprehensive view of available drug information on the potential side effects when taking this medication. Cefazolin injection comes as a powder to be mixed with liquid, or as a premixed product, to be injected intravenously into a vein over a period of 30 minutes. There is clinical evidence of partial crossallergenicity of the penicillins and the cephalosporins. If you are taking birth control pills, warfarin, or certain antibiotics, talk to your healthcare provider about whether these products might cause drug interactions with cefazolin. As with other cephalosporins, cefazolin for injection, usp tends to darken depending on storage conditions. Patients who receive a single dose of an iv cephalosporin prior to an operative procedure may develop jaundice and biochemical cholestasis weeks later. Cefazolin for injection usp and dextrose injection usp fda. A pharmacy bulk package is sterile dosage form for parenteral use that contains many single doses. Cefazolin is present in very low concentrations in the milk of nursing mothers. Sandoz inc cefazolin cefazolin sodium injection, powder. Cefazolin definition of cefazolin by the free dictionary. Cefazolin has had extensive clinical use and has proven effectiveness.
This medication is known as a cephalosporin antibiotic. So each dose administered would be between 7503000mg, depending on the severity of the infection being treated. Ancef cefazolin is only available as an injectable, so it is usually only used in the hospital. Cefazolin for injection usp, 1g, 25x10ml injectable vial. Cefazolin is an antibiotic used to treat a wide variety of bacterial infections. Monographs for commonly administered intravenous medications. Some of these reactions may lead to a decreased effectiveness of the medicine or increase your risk for side effects, among other things. Jul 12, 2018 cefazolin passes into breast milk in very low concentrations. One vial of cefazolin sodium 540 mg equivalent to 500 mg cefazolin. Dailymed cefazolin injection, powder, for solution. It is used to treat or prevent certain kinds of bacterial infections. Determine any previous allergic reactions towards antibiotics, especially penicillin. Cefazolin for injection is present in very low concentrations in the milk of nursing mothers. Stability of cefazolin sodium in polypropylene syringes and polyvinylchloride minibags article pdf available in the canadian journal of hospital pharmacy 644.
Mar 19, 2019 ancef package insert pdf march 19, 2019 posted by admin cefazolin for injection and other antibacterial drugs, cefazolin for injection should be a pharmacy bulk package is sterile dosage form for parenteral use that. Cefazolin for injection usp, pharmacy bulk package bag smartpak should not be used in patients who require less than a 250 mg dose of cefazolin. Highlights of prescribing information 250 mg and 125 mg. Due to the unprecedented nature of the covid19 pandemic, anyone reporting an adverse event andor a product complaint via phone, should you receive a network busy signal ie. For intravenous use only over approximately 30 minutes. Some health conditions may make you more susceptible to the sideeffects of the drug. The peak level in serum is approximately 3242 mgml after an intramuscular im injection of 500 mg. Cefazolin injection is a cephalosporin antibacterial indicated for preoperative prophylaxis. If you use other drugs or over the counter products at the same time, the effects of cefazolin injection may change. Naropin ropivacaine hcl injection a fresenius kabi site. Nov 14, 2018 cefazolin for injection, usp is a white to cream sterile powder. When reconstituted as directed each 10 ml contains 500 mg and each 20 ml contains 1 gram.
1300 298 1442 1041 1471 1071 1223 47 1458 330 417 979 577 482 440 1224 1112 352 216 915 1424 728 1527 743 192 1128 11 621 421 671 770 1395 339 953 1442 1082